The continuous development of resistance by microorganisms to antibiotics has necessitated the use of combinations of agents for their containment. This has led to the combination of plant products or parts known to have potentials to control microorganisms with antibiotics without any scientific basis by traditional medicine practitioners. Erythromycin and Streptomycin were differently combined with concentrations of Blighia sapida previously known to control Staphylococcus aureus in anticipation of a synergistic or at least additive effect using both the Agar well diffusion method and strip - agar methods. Results obtained showed an undesirable antagonistic effect leading to a complete loss of activity in the case of Erythromycin against Escherichia coli and reduction in activity of streptomycin against both Escherichia coli and Pseudomonas aeruginosa. Plant product-antibiotic combinations in anticipation of synergism should not be done without scientific proof.
| Published in | American Journal of Life Sciences (Volume 3, Issue 1) |
| DOI | 10.11648/j.ajls.20150301.11 |
| Page(s) | 1-5 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Resistance, Combination, Plant Products, Synergism, Antagonism
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APA Style
Udobi Chinweizu Ejikeme, Daniel Mbuotidem David. (2015). Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism. American Journal of Life Sciences, 3(1), 1-5. https://doi.org/10.11648/j.ajls.20150301.11
ACS Style
Udobi Chinweizu Ejikeme; Daniel Mbuotidem David. Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism. Am. J. Life Sci. 2015, 3(1), 1-5. doi: 10.11648/j.ajls.20150301.11
AMA Style
Udobi Chinweizu Ejikeme, Daniel Mbuotidem David. Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism. Am J Life Sci. 2015;3(1):1-5. doi: 10.11648/j.ajls.20150301.11
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Download@article{10.11648/j.ajls.20150301.11,
author = {Udobi Chinweizu Ejikeme and Daniel Mbuotidem David},
title = {Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism},
journal = {American Journal of Life Sciences},
volume = {3},
number = {1},
pages = {1-5},
doi = {10.11648/j.ajls.20150301.11},
url = {https://doi.org/10.11648/j.ajls.20150301.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150301.11},
abstract = {The continuous development of resistance by microorganisms to antibiotics has necessitated the use of combinations of agents for their containment. This has led to the combination of plant products or parts known to have potentials to control microorganisms with antibiotics without any scientific basis by traditional medicine practitioners. Erythromycin and Streptomycin were differently combined with concentrations of Blighia sapida previously known to control Staphylococcus aureus in anticipation of a synergistic or at least additive effect using both the Agar well diffusion method and strip - agar methods. Results obtained showed an undesirable antagonistic effect leading to a complete loss of activity in the case of Erythromycin against Escherichia coli and reduction in activity of streptomycin against both Escherichia coli and Pseudomonas aeruginosa. Plant product-antibiotic combinations in anticipation of synergism should not be done without scientific proof.},
year = {2015}
}
TY - JOUR T1 - Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism AU - Udobi Chinweizu Ejikeme AU - Daniel Mbuotidem David Y1 - 2015/01/14 PY - 2015 N1 - https://doi.org/10.11648/j.ajls.20150301.11 DO - 10.11648/j.ajls.20150301.11 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 1 EP - 5 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.20150301.11 AB - The continuous development of resistance by microorganisms to antibiotics has necessitated the use of combinations of agents for their containment. This has led to the combination of plant products or parts known to have potentials to control microorganisms with antibiotics without any scientific basis by traditional medicine practitioners. Erythromycin and Streptomycin were differently combined with concentrations of Blighia sapida previously known to control Staphylococcus aureus in anticipation of a synergistic or at least additive effect using both the Agar well diffusion method and strip - agar methods. Results obtained showed an undesirable antagonistic effect leading to a complete loss of activity in the case of Erythromycin against Escherichia coli and reduction in activity of streptomycin against both Escherichia coli and Pseudomonas aeruginosa. Plant product-antibiotic combinations in anticipation of synergism should not be done without scientific proof. VL - 3 IS - 1 ER -
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