Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population

Diez-Ojea Beatriz; Marin Rafael; Coto Eliecer; Tavira Beatriz; Fernandez-Vega Francisco; Alvarez Rafael; Fernandez-Fresnedo Gema; Pobes Alfonso; Suarez-Laures Ana; Garcia-Monteavaro Camino; Gorostidi Manuel; Sanchez Emilio; Arias Manuel; Ortega Francisco

doi:doi:10.11648/j.ajim.20140206.11

Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population

Diez-Ojea Beatriz, Marin Rafael, Coto Eliecer, Tavira Beatriz, Fernandez-Vega Francisco, Alvarez Rafael, Fernandez-Fresnedo Gema, Pobes Alfonso, Suarez-Laures Ana, Garcia-Monteavaro Camino, Gorostidi Manuel, Sanchez Emilio, Arias Manuel, Ortega Francisco

Published in American Journal of Internal Medicine (Volume 2, Issue 6)

Received: 8 September 2014 Accepted: 25 September 2014 Published: 30 October 2014

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Abstract

Background: Hypertensive nephrosclerosis (HN) is a chronic kidney disease (CKD) associated to essential hypertension, but their causal relationship is controversial. New evidence suggests that MYH9 gene alterations are associated with HN in African Americans. The aim of this study is to investigate the role of this gene in Spanish Caucasians. Methods: We compare high-risk MYH9 variants of patients with HN recruited according to standard clinical criteria (CKD stages 3-5), with essential hypertensives without renal disease (estimated glomerular filtration rate (eGFR) > 60 ml/min/1,73m2 and albuminuria < 300 mg/g creatinine), and also CKD patients with HN and progressive impairment of renal function with those who were stable. Diabetics were excluded. Results: A blood sample was obtained for genetic study of 238 patients with HN-CKD and 233 hypertensive controls. The rs3752462-T and rs4821480-T (risk alleles for CKD) were more frequent in the CKD group, but without significant difference. We found no differences for these SPNs with blood pressure, creatinine, albuminuria or renal disease progression. Conclusions: The effect of two common MYH9 single nucleotide polymorphisms (SPNs) on the development of CKD secondary to HN in our Spanish Caucasian population is low or zero; in any case less than that found in other, mainly African Americans.

Published in	American Journal of Internal Medicine (Volume 2, Issue 6)
DOI	10.11648/j.ajim.20140206.11
Page(s)	95-101
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Chronic Kidney Disease, Essential Hypertension, Hypertensive Nephrosclerosis, MYH9 Polymorphisms

References

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[17]	Diez Ojea B, Marin R, Coto E, et al. Clinical and genetic bases of Hipertensive Nephrosclerosis. NEFROSEN Study. Nefrología 2010;30(6):687-97.
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APA Style

Diez-Ojea Beatriz, Marin Rafael, Coto Eliecer, Tavira Beatriz, Fernandez-Vega Francisco, et al. (2014). Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population. American Journal of Internal Medicine, 2(6), 95-101. https://doi.org/10.11648/j.ajim.20140206.11

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ACS Style

Diez-Ojea Beatriz; Marin Rafael; Coto Eliecer; Tavira Beatriz; Fernandez-Vega Francisco, et al. Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population. Am. J. Intern. Med. 2014, 2(6), 95-101. doi: 10.11648/j.ajim.20140206.11

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AMA Style

Diez-Ojea Beatriz, Marin Rafael, Coto Eliecer, Tavira Beatriz, Fernandez-Vega Francisco, et al. Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population. Am J Intern Med. 2014;2(6):95-101. doi: 10.11648/j.ajim.20140206.11

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@article{10.11648/j.ajim.20140206.11,
  author = {Diez-Ojea Beatriz and Marin Rafael and Coto Eliecer and Tavira Beatriz and Fernandez-Vega Francisco and Alvarez Rafael and Fernandez-Fresnedo Gema and Pobes Alfonso and Suarez-Laures Ana and Garcia-Monteavaro Camino and Gorostidi Manuel and Sanchez Emilio and Arias Manuel and Ortega Francisco},
  title = {Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population},
  journal = {American Journal of Internal Medicine},
  volume = {2},
  number = {6},
  pages = {95-101},
  doi = {10.11648/j.ajim.20140206.11},
  url = {https://doi.org/10.11648/j.ajim.20140206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20140206.11},
  abstract = {Background: Hypertensive nephrosclerosis (HN) is a chronic kidney disease (CKD) associated to essential hypertension, but their causal relationship is controversial. New evidence suggests that MYH9 gene alterations are associated with HN in African Americans. The aim of this study is to investigate the role of this gene in Spanish Caucasians. Methods: We compare high-risk MYH9 variants of patients with HN recruited according to standard clinical criteria (CKD stages 3-5), with essential hypertensives without renal disease (estimated glomerular filtration rate (eGFR) > 60 ml/min/1,73m2 and albuminuria < 300 mg/g creatinine), and also CKD patients with HN and progressive impairment of renal function with those who were stable. Diabetics were excluded. Results: A blood sample was obtained for genetic study of 238 patients with HN-CKD and 233 hypertensive controls. The rs3752462-T and rs4821480-T (risk alleles for CKD) were more frequent in the CKD group, but without significant difference. We found no differences for these SPNs with blood pressure, creatinine, albuminuria or renal disease progression. Conclusions: The effect of two common MYH9 single nucleotide polymorphisms (SPNs) on the development of CKD secondary to HN in our Spanish Caucasian population is low or zero; in any case less than that found in other, mainly African Americans.},
 year = {2014}
}

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TY  - JOUR
T1  - Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population
AU  - Diez-Ojea Beatriz
AU  - Marin Rafael
AU  - Coto Eliecer
AU  - Tavira Beatriz
AU  - Fernandez-Vega Francisco
AU  - Alvarez Rafael
AU  - Fernandez-Fresnedo Gema
AU  - Pobes Alfonso
AU  - Suarez-Laures Ana
AU  - Garcia-Monteavaro Camino
AU  - Gorostidi Manuel
AU  - Sanchez Emilio
AU  - Arias Manuel
AU  - Ortega Francisco
Y1  - 2014/10/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ajim.20140206.11
DO  - 10.11648/j.ajim.20140206.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 95
EP  - 101
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20140206.11
AB  - Background: Hypertensive nephrosclerosis (HN) is a chronic kidney disease (CKD) associated to essential hypertension, but their causal relationship is controversial. New evidence suggests that MYH9 gene alterations are associated with HN in African Americans. The aim of this study is to investigate the role of this gene in Spanish Caucasians. Methods: We compare high-risk MYH9 variants of patients with HN recruited according to standard clinical criteria (CKD stages 3-5), with essential hypertensives without renal disease (estimated glomerular filtration rate (eGFR) > 60 ml/min/1,73m2 and albuminuria < 300 mg/g creatinine), and also CKD patients with HN and progressive impairment of renal function with those who were stable. Diabetics were excluded. Results: A blood sample was obtained for genetic study of 238 patients with HN-CKD and 233 hypertensive controls. The rs3752462-T and rs4821480-T (risk alleles for CKD) were more frequent in the CKD group, but without significant difference. We found no differences for these SPNs with blood pressure, creatinine, albuminuria or renal disease progression. Conclusions: The effect of two common MYH9 single nucleotide polymorphisms (SPNs) on the development of CKD secondary to HN in our Spanish Caucasian population is low or zero; in any case less than that found in other, mainly African Americans.
VL  - 2
IS  - 6
ER  -

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Author Information

Diez-Ojea Beatriz

Nephrology Service, Hospital Universitario De Torrevieja-Vinalopo, Alicante, Spain
Marin Rafael

Nephrology Service, Centro Médico De Asturias, Oviedo (Asturias), Spain
Coto Eliecer

Laboratory of Molecular Genetics, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain
Tavira Beatriz

Laboratory of Molecular Genetics, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain
Fernandez-Vega Francisco

Nephrology Service, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain
Alvarez Rafael

Nephrology Service, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain
Fernandez-Fresnedo Gema

Nephrology Service, Hospital Universitario Marqués De Valdecilla, Santander (Cantabria), Spain
Pobes Alfonso

Nephrology Service, Hospital Valle Del Nalón, Langreo (Asturias), Spain
Suarez-Laures Ana

Nephrology Service, Hospital De Cabue?es, Gijón (Asturias), Spain
Garcia-Monteavaro Camino

Nephrology Service, Hospital San Agustín, Avilés (Asturias), Spain
Gorostidi Manuel

Nephrology Service, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain
Sanchez Emilio

Nephrology Service, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain
Arias Manuel

Nephrology Service, Hospital Universitario Marqués De Valdecilla, Santander (Cantabria), Spain
Ortega Francisco

Nephrology Service, Hospital Universitario Central De Asturias, Oviedo (Asturias), Spain

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Plain Text BibTeX RIS

APA Style

Diez-Ojea Beatriz, Marin Rafael, Coto Eliecer, Tavira Beatriz, Fernandez-Vega Francisco, et al. (2014). Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population. American Journal of Internal Medicine, 2(6), 95-101. https://doi.org/10.11648/j.ajim.20140206.11

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ACS Style

Diez-Ojea Beatriz; Marin Rafael; Coto Eliecer; Tavira Beatriz; Fernandez-Vega Francisco, et al. Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population. Am. J. Intern. Med. 2014, 2(6), 95-101. doi: 10.11648/j.ajim.20140206.11

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AMA Style

Diez-Ojea Beatriz, Marin Rafael, Coto Eliecer, Tavira Beatriz, Fernandez-Vega Francisco, et al. Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population. Am J Intern Med. 2014;2(6):95-101. doi: 10.11648/j.ajim.20140206.11

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@article{10.11648/j.ajim.20140206.11,
  author = {Diez-Ojea Beatriz and Marin Rafael and Coto Eliecer and Tavira Beatriz and Fernandez-Vega Francisco and Alvarez Rafael and Fernandez-Fresnedo Gema and Pobes Alfonso and Suarez-Laures Ana and Garcia-Monteavaro Camino and Gorostidi Manuel and Sanchez Emilio and Arias Manuel and Ortega Francisco},
  title = {Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population},
  journal = {American Journal of Internal Medicine},
  volume = {2},
  number = {6},
  pages = {95-101},
  doi = {10.11648/j.ajim.20140206.11},
  url = {https://doi.org/10.11648/j.ajim.20140206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20140206.11},
  abstract = {Background: Hypertensive nephrosclerosis (HN) is a chronic kidney disease (CKD) associated to essential hypertension, but their causal relationship is controversial. New evidence suggests that MYH9 gene alterations are associated with HN in African Americans. The aim of this study is to investigate the role of this gene in Spanish Caucasians. Methods: We compare high-risk MYH9 variants of patients with HN recruited according to standard clinical criteria (CKD stages 3-5), with essential hypertensives without renal disease (estimated glomerular filtration rate (eGFR) > 60 ml/min/1,73m2 and albuminuria < 300 mg/g creatinine), and also CKD patients with HN and progressive impairment of renal function with those who were stable. Diabetics were excluded. Results: A blood sample was obtained for genetic study of 238 patients with HN-CKD and 233 hypertensive controls. The rs3752462-T and rs4821480-T (risk alleles for CKD) were more frequent in the CKD group, but without significant difference. We found no differences for these SPNs with blood pressure, creatinine, albuminuria or renal disease progression. Conclusions: The effect of two common MYH9 single nucleotide polymorphisms (SPNs) on the development of CKD secondary to HN in our Spanish Caucasian population is low or zero; in any case less than that found in other, mainly African Americans.},
 year = {2014}
}

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TY  - JOUR
T1  - Association of the MYH9 Gene Polymorphisms with Chronic Renal Disease Secondary to Hypertensive Nephrosclerosis, in a Caucasian Population
AU  - Diez-Ojea Beatriz
AU  - Marin Rafael
AU  - Coto Eliecer
AU  - Tavira Beatriz
AU  - Fernandez-Vega Francisco
AU  - Alvarez Rafael
AU  - Fernandez-Fresnedo Gema
AU  - Pobes Alfonso
AU  - Suarez-Laures Ana
AU  - Garcia-Monteavaro Camino
AU  - Gorostidi Manuel
AU  - Sanchez Emilio
AU  - Arias Manuel
AU  - Ortega Francisco
Y1  - 2014/10/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ajim.20140206.11
DO  - 10.11648/j.ajim.20140206.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 95
EP  - 101
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20140206.11
AB  - Background: Hypertensive nephrosclerosis (HN) is a chronic kidney disease (CKD) associated to essential hypertension, but their causal relationship is controversial. New evidence suggests that MYH9 gene alterations are associated with HN in African Americans. The aim of this study is to investigate the role of this gene in Spanish Caucasians. Methods: We compare high-risk MYH9 variants of patients with HN recruited according to standard clinical criteria (CKD stages 3-5), with essential hypertensives without renal disease (estimated glomerular filtration rate (eGFR) > 60 ml/min/1,73m2 and albuminuria < 300 mg/g creatinine), and also CKD patients with HN and progressive impairment of renal function with those who were stable. Diabetics were excluded. Results: A blood sample was obtained for genetic study of 238 patients with HN-CKD and 233 hypertensive controls. The rs3752462-T and rs4821480-T (risk alleles for CKD) were more frequent in the CKD group, but without significant difference. We found no differences for these SPNs with blood pressure, creatinine, albuminuria or renal disease progression. Conclusions: The effect of two common MYH9 single nucleotide polymorphisms (SPNs) on the development of CKD secondary to HN in our Spanish Caucasian population is low or zero; in any case less than that found in other, mainly African Americans.
VL  - 2
IS  - 6
ER  -

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